Biotechnology
2-2008-20 Collagen fibers from a soft coral: A novel source of scaffolding
material for tissue engineering
A novel source of collagen manifested as fibers derived from certain species of
soft corals has been isolated. The New Collagen fibers are strong and
flexible compared to commercial collagen. The fibers have a high
reversible extensibility
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Novel carrier proteins derived from staphylococcus nuclease for high yield
peptide production, L-11391
Novel carrier proteins for the production of small or large peptides as
recombinant fusion proteins
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Simple and efficient method for the large-scale production of E1 deficient
adenovirus, L-10624
This technology provides a vector and a cell line that enables easy production
of replicant
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Stabilisation of biopharmaceuticals
Increasing the stability and improving the reconstitution of biomolecules using
supercritical fluid (SCF) processing
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Cardiovascular
Cardiovascular risk assessment (02-01)
Diagnosis of functional heart disease and heart disease prognostication with
emphasis on the multifractal alpha, the Levy flight analysis and the key
discrete wavelet smoothing
more
N-Methyl-D-Aspartate (NMDA) receptor blockers for the prevention of
atherosclerosis (TID - 69)
A novel series of NMDA receptor antagonists, which shows different selectivity
for NMDA receptors than the previously described NMDA receptor antagonists
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Central Nervous System
Multiactivity glutamic acid derivatives and their potential usefulness in the
treatment of alzheimer’s disease
CSIC has patented a series of new glutamic acid derivatives that show several
pharmacological activities in a single small molecule, particularly in a
potential treatment of the alzheimer’s disease
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Prevention of hydrocephalus
Prevention of hydrocephalus. The supplement is a dual-combination therapy
comprising safe, natural compounds
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Screening of inhibitors of a new target for parkinson’s disease (LRRK2)
using cell assays
We have designed a faster and more reliable method to identify inhibitors of
LRRK2 and the lysosomal two-pore channel, potential therapeutic targets for
Parkinson’s disease by determining, in cell cultures, autophagy rate,
lysosomal pH and cell death
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Diagnostic
iPump - the image pumping utility to bridge the gap between IGRT and RV systems
in radiation therapy (08-05)
Method and system for image pumping - software
more
Drug delivery
10-2008-112 Gagomers - novel drug delivery system for the delivery of proteins
to the brain
Gagomers are novel particles (neither liposomes nor microspheres/nanospheres)
composed of hyaluronan shell which is crossed linked via phospholipids. Gagomers
could be generated either as micro or nano particles. The research team at Tel
Aviv University
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Product enhancement of small and large molecules in a range of dosage forms
Proprietary supercritical fluid (SCF) technology to improve bioavailability,
enhance stability and optimise drug delivery for small and large molecules in a
range of dosage forms
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Tackling challenges of poor solubility
Enhancing the dissolution performance of small and large molecules in a range of
dosage forms
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Gastrointestinal
Peptide that prevents gastrointestinal infections (TID - 86)
A therapeutic peptide that can prevent intestinal infections by increasing the
expression of MUC3 by intestinal epithelial cells
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Genito-urinary
Acute renal failure target (95-04)
Acute renal failure target - calcium independent phospholipase A2
more
Instead fertility cup
Conception aid, fertility cup
more
Instead® Softcup™ - revolutionary menstrual protection
Superior alternative to pads and tampons
more
Radiation dialysis and antegrade arterial access sheath (TID - 202)
Allows greater flexibility for the dialysis patient. Current methods are
dangerous and sometimes difficult for dialysis procedures. Can be used for
antegrade arterial access from CFA approach. Other applications could be use for
biliary and renal procedur
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Hospital and Surgery
2-2010-9 Guided regeneration gel: a novel biocompatible hydrogel for peripheral
nerve reconstruction and wound healing
Guided regeneration gel (GRG) is a novel biocompatible, biodegradable hydrogel
for peripheral nerve reconstruction and wound healing
more
Compositions and methods for improved organ transplant outcomes: tissue
protection during transport and storage (10-05)
Protection against injury to organs or tissues during pre-transplant storage and
transport
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Novel anaesthetic breathing system
Breathing system which scavenges anaesthetic gases to prevent surgical staff
from unnecessary exposure
more
Topical anesthetic for long-term care market
Topical anesthetic for long-term care market
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Immune related disorders
Butyric acid - derivatives of (99-03)
Derivatives of butyric acid and uses thereof - treatment of autoimmune
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Infectious diseases
A physical method for the quantification of viruses and viral particles
(L-11622)
This technology allows for the direct, simple and rapid count of the effective
number of viruses or viral particles present in a sample
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Metabolism
Bivalent pyrazole derivatives as food intake inhibitors
New bivalent pyrazole derivatives that bind, as antagonist ligands, to
cannabinoid receptors and are capable of inhibiting the appetite. These
compounds could be effective against obesity, diabetes and metabolic disorders
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Cogenzia®
Indicated for the treatment and prevention of diabetic foot ulcers
more
Detection of alcohol liver disease (TID - 58)
The use of this technology could lead to improved diagnosis of individuals with
early stage liver disease
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Oncology
Novel RNA biomarker, transcript variants of SLC3A914, for colorectal cancer
SLC3A914 - RNA biomarker for colorectal cancer
more
Test for cancer diagnosis based in the quantification of acid ceramidase
A fluorimetry method determining lysosomal acid ceramidase as biomarker for
diagnosis of several types of cancer. It avoids interferences (e.g. with other
ceramidases) and the use of radioactivity, is highly sensitive (pmol) and
reduces the analysis time
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Tumour vascular targeting agents
Novel series of heterocyclic compounds which have been tested and screened for
growth inhibitory activity (IC50) against the K562 human chronic myelogenous
leukemia cell-line using the MTT assay and for their ability to inhibit the
tubulin assembly
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