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Out-licensing: Disease mice models available for licensing
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Out-licensing

Disease mice models available for licensing

BONAC Corporation
We are conducting developmental research on disease model mice related to the development of nucleic acid medicines (RNAi, aptamer, antisense, etc.).

Full description

We are conducting developmental research on disease model mice related to the development of nucleic acid medicines (RNAi, aptamer, antisense, etc.). Currently, we are preparing and developing the following model mice at the BONAC disease model department. These disease mouse models are available for licensing.

  • Pulmonary hypertension
  • Acute lung injury (ALI)
  • Pulmonary fibrosis
  • Allergic bronchial asthma
  • Airway remodeling, upper respiratory tract inflammation (rhinitis etc.)
  • Diabetes, diabetic nephropathy
  • Chronic glomerulonephritis
  • Obstructive nephropathy
  • Hypertension, aortic aneurysm, arteriosclerosis
  • Atopic dermatitis
  • Canceration, cancer invasion, distant metastasis model
  • Ichorrhemia, thrombosis
  • Hepatitis, fulminant hepatitis, cirrhosis model
  • Obstructive jaundice model


Lung-specific human TGF-β1 transgenic mouse for lung injury model:

  • Pulmonary fibrosis is a devastating disease with a reported survival rate of 30% after the onset. It is accompanied by stiffness of lung tissue that makes it hard for the sufferer to breathe. At present no specific drugs are available.
  • In order to develop a nucleic acid medicine of pulmonary fibrosis, we prepared a model mouse of spontaneous pulmonary fibrosis.
  • It has been known that TGF-β1 induces the expression of type I collagen and enhances its deposition. We prepared a model mouse of spontaneous pulmonary fibrosis by overexpressing human TGF-β1 in mouse specific to lung.
  • This transgenic mouse model is also available for licensing.

Development status

Preclinical

Type of business relationship sought

Licensing of the company's platform technology including the collaborative research agreement.

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78SELECT `par`.`uid`, `par`.`name`, `Category`.`uid` FROM `category` AS `Category` JOIN category AS `par` ON (`Category`.`lft` BETWEEN `par`.`lft` AND `par`.`rgt` AND `par`.`level` >= 2) LEFT JOIN `category` AS `Parent` ON (`Category`.`parent` = `Parent`.`uid`) LEFT JOIN `categories_sites` AS `CategorySite` ON (`CategorySite`.`category_id` = `Category`.`uid`) WHERE `CategorySite`.`site_id` = 1 AND `Category`.`uid` = 1879 ORDER BY `par`.`lft` ASC 330
79SELECT `Child`.`uid`, `Child`.`name`, `Child`.`parent`, `Child`.`has_children`, `Child`.`show_children`, `Child`.`show_grandchildren`, `Child`.`members`, `Child`.`num_children`, `Child`.`root`, `Child`.`restricted`, `Child`.`clan`, `Child`.`lft`, `Child`.`rgt`, `Child`.`level` FROM `category` AS `Child` WHERE `Child`.`parent` = (1879) ORDER BY `name` ASC 000
80SELECT `par`.`uid`, `par`.`name`, `Category`.`uid` FROM `category` AS `Category` JOIN category AS `par` ON (`Category`.`lft` BETWEEN `par`.`lft` AND `par`.`rgt` AND `par`.`level` >= 2) LEFT JOIN `category` AS `Parent` ON (`Category`.`parent` = `Parent`.`uid`) LEFT JOIN `categories_sites` AS `CategorySite` ON (`CategorySite`.`category_id` = `Category`.`uid`) WHERE `CategorySite`.`site_id` = 1 AND `Category`.`uid` = 1881 ORDER BY `par`.`lft` ASC 220
81SELECT `Child`.`uid`, `Child`.`name`, `Child`.`parent`, `Child`.`has_children`, `Child`.`show_children`, `Child`.`show_grandchildren`, `Child`.`members`, `Child`.`num_children`, `Child`.`root`, `Child`.`restricted`, `Child`.`clan`, `Child`.`lft`, `Child`.`rgt`, `Child`.`level` FROM `category` AS `Child` WHERE `Child`.`parent` = (1881) ORDER BY `name` ASC 770
82SELECT `par`.`uid`, `par`.`name`, `Category`.`uid` FROM `category` AS `Category` JOIN category AS `par` ON (`Category`.`lft` BETWEEN `par`.`lft` AND `par`.`rgt` AND `par`.`level` >= 2) LEFT JOIN `category` AS `Parent` ON (`Category`.`parent` = `Parent`.`uid`) LEFT JOIN `categories_sites` AS `CategorySite` ON (`CategorySite`.`category_id` = `Category`.`uid`) WHERE `CategorySite`.`site_id` = 1 AND `Category`.`uid` = 2125 ORDER BY `par`.`lft` ASC 220
83SELECT `Child`.`uid`, `Child`.`name`, `Child`.`parent`, `Child`.`has_children`, `Child`.`show_children`, `Child`.`show_grandchildren`, `Child`.`members`, `Child`.`num_children`, `Child`.`root`, `Child`.`restricted`, `Child`.`clan`, `Child`.`lft`, `Child`.`rgt`, `Child`.`level` FROM `category` AS `Child` WHERE `Child`.`parent` = (2125) ORDER BY `name` ASC 14140
84SELECT l.uid, l.slug, l.title, l.shortdesc, sum(c.level) AS score FROM licopp l INNER JOIN categorisation ctg ON ctg.company_id = l.uid AND ctg.cat_type = "L" INNER JOIN categorisation ctg2 ON ctg.category_id = ctg2.category_id AND ctg2.company_id = "19392" AND ctg2.cat_type = "L" INNER JOIN category c ON ctg.category_id = c.uid WHERE l.uid <> 19392 AND c.root = 560 GROUP BY l.uid, l.title, l.shortdesc ORDER BY score DESC, l.viewed_counter DESC LIMIT 5 55878
85SELECT Authority.user_id FROM authority AS Authority WHERE company_id = 21173 ORDER BY primary_user DESC110
86SELECT `Site`.`id`, `Site`.`name`, `Site`.`email_domain`, `Site`.`short_name`, `Site`.`brand` FROM `sites` AS `Site` WHERE `Site`.`id` = 1 LIMIT 1110
87UPDATE licopp SET viewed_counter = viewed_counter + 1 WHERE uid = 19392 16
88SELECT `Outlicensing`.`company_id` FROM `licopp` AS `Outlicensing` LEFT JOIN `licopps_sites` AS `OutlicensingSite` ON (`OutlicensingSite`.`licopp_id` = `Outlicensing`.`uid`) WHERE `OutlicensingSite`.`site_id` = 1 AND `Outlicensing`.`uid` = 19392 LIMIT 1111
89DESCRIBE `statistics`771
90SELECT `ModuleType`.`id`, `ModuleType`.`handle`, `ModuleType`.`name`, `ModuleType`.`description`, `ModuleType`.`created`, `ModuleType`.`modified` FROM `module_types` AS `ModuleType` WHERE `ModuleType`.`handle` = 'outlicensing' LIMIT 1110
91SELECT `Statistic`.`id`, `Statistic`.`module_type_id`, `Statistic`.`company_id`, `Statistic`.`business_object_id`, `Statistic`.`count`, `Statistic`.`hit_date`, `Statistic`.`is_aggregated`, `ModuleType`.`id`, `ModuleType`.`handle`, `ModuleType`.`name`, `ModuleType`.`description`, `ModuleType`.`created`, `ModuleType`.`modified` FROM `statistics` AS `Statistic` LEFT JOIN `module_types` AS `ModuleType` ON (`Statistic`.`module_type_id` = `ModuleType`.`id`) WHERE `business_object_id` = '19392' AND `company_id` = 21173 AND `module_type_id` = '4' AND `hit_date` = '2012-05-21' LIMIT 1001
92INSERT INTO `statistics` (`is_aggregated`, `count`, `company_id`, `business_object_id`, `module_type_id`, `hit_date`) VALUES (0, 1, 21173, '19392', '4', '2012-05-21')10
93SELECT LAST_INSERT_ID() AS insertID110
(default) 0 query took ms
NrQueryErrorAffectedNum. rowsTook (ms)
(report) 2 queries took 95 ms
NrQueryErrorAffectedNum. rowsTook (ms)
1DESCRIBE `reports`17171
2SELECT `MarketResearchReport`.`id`, `MarketResearchReport`.`slug`, `MarketResearchReport`.`name`, `MarketResearchReport`.`description`, `MarketResearchReport`.`summary`, `MarketResearchReport`.`content`, `MarketResearchReport`.`isbn`, `MarketResearchReport`.`code`, `MarketResearchReport`.`pages`, `MarketResearchReport`.`published`, `MarketResearchReport`.`net_price_usd`, `MarketResearchReport`.`active`, `MarketResearchReport`.`publisher_id`, `MarketResearchReport`.`views`, `MarketResearchReport`.`tags`, `MarketResearchReport`.`created`, `MarketResearchReport`.`modified` FROM `reports` AS `MarketResearchReport` WHERE `MarketResearchReport`.`active` = 1 AND MATCH (`MarketResearchReport`.`name`, `MarketResearchReport`.`description`, `MarketResearchReport`.`summary`, `MarketResearchReport`.`content`, `MarketResearchReport`.`isbn`, `MarketResearchReport`.`code`) AGAINST ("Disease mice models available for licensing") ORDER BY MATCH (`MarketResearchReport`.`name`, `MarketResearchReport`.`description`, `MarketResearchReport`.`summary`, `MarketResearchReport`.`content`, `MarketResearchReport`.`isbn`, `MarketResearchReport`.`code`) AGAINST ("Disease mice models available for licensing") DESC , MarketResearchReport.published DESC LIMIT 10101094